How Different Antidepressants Work

I’ve taken some excerpts from WebMD explaining how antidepressants work. Please click here for the link if you care to read it in its entirety.

Note: Using WebMD as a source is not necessarily an endorsement of WebMD. While they have much good information, they also promote misinformation, especially when discussing diet and nutrition. Consider this:

Cut back on Fats and Oils: Eating too many fats can cause high cholesterol and heart disease. With DASH [Dietary Approaches to Stop Hypertension], you’ll limit fats and oils to two to three servings a day. A serving is 1 teaspoon of margarine or vegetable oil, 1 tablespoon of mayonnaise, or 2 tablespoons of low-fat salad dressing. When cooking, use vegetable oils like olive or canola instead of butter.

Soybean oil, canola oil, and cottonseed oil are the worst of the worst fats and should be avoided. For those that followed our reviews and digests of Dr. Stephen Sinatra’s The Great Cholesterol Myth, these already oxidized, seed-based* oils are high in Omega 6 fatty acids. Omega 6 oil are very unstable when heated *Calling them vegetable oils is a misnomer. You get oil from seeds, not vegetables.

Factory, high temperature processing causes these oils to become rancid or oxidized by the time you buy them. Because they are rancid, they throw off free radicals right and left.  When you consume them, this contributes to turning harmless, low-density lipo-proteins into bad cholesterol which in turn, leads to inflammation of your coronary arteries.

Yes, WebMD is still on the bandwagon of demonizing cholesterol. The fact that a supposed “health” website supports the use of margarine, a transfat, suggests that they have an agenda, one that does not have your health in mind.

WebMD has a bias that favors the use of pharmaceutical drugs and processed factory foods. Sites such as WebMD may also be the recipient of hidden corporate sponsorship. If a soybean oil processor, for example, is funding WebMD, that gives WebMD motive for demonizing butter and promoting seed [vegetable] oils and soy-based foods. Condoning the use of margarine, a transfat, is a dead giveaway.

For more revealing information about WebMD, please click here and here.

With these caveats in mind concerning WebMD, let’s learn about the pharmacology behind commonly prescribed antidepressants.

Reuptake Inhibitors: SSRIs, SNRIs, and NDRIs

…We really don’t know what causes depression or how it affects the brain. We don’t exactly know how antidepressants improve the symptoms.

That said, many researchers believe that the benefits of antidepressants stem from how they affect certain brain circuits and the chemicals (called neurotransmitters) that pass along signals from one nerve cell to another in the brain. These chemicals include serotonin, dopamine, and norepinephrine. In various ways, different antidepressants seem to affect how these neurotransmitters behave. Here’s a rundown of the main types of antidepressants…

Some of the most commonly prescribed antidepressants are called reuptake inhibitors. What’s reuptake? It’s the process in which neurotransmitters are naturally reabsorbed back into nerve cells in the brain after they are released to send messages between nerve cells. A reuptake inhibitor prevents this from happening. Instead of getting reabsorbed, the neurotransmitter stays — at least temporarily — in the gap between the nerves, called the synapse.

What’s the benefit? The basic theory goes like this: keeping levels of the neurotransmitters higher could improve communication between the nerve cells — and that can strengthen circuits in the brain which regulate mood.

My comment: simply put, an SSRI slows down the use or reuptake of your serotonin, causing it to last longer in your nerve synapses.

Continuing:

Different kinds of reuptake inhibitors target different neurotransmitters. There are three types:

Selective serotonin reuptake inhibitors (SSRIs) are some of the most commonly prescribed antidepressants available. They include Celexa, Lexapro, Luvox, Paxil, Prozac, and Zoloft. Another drug, Symbyax, is approved by the FDA specifically for treatment-resistant depression. It’s a combination of the SSRI antidepressant fluoxetine (Prozac) and another drug approved for bipolar disorder and schizophrenia called olanzapine (Zyprexa). Aripiprazole (Abilify), quetiapine (Seroquel), and brexpiprazole (Rexulti) have been FDA approved as add-on therapy to antidepressants for depression. Plus, doctors often use other drugs in combination for treatment-resistant depression. Also, the drugs  vilazodone (Viibryd) and vortioxetine (Trintellix – formelrly called Brintellix) are among the newest antidepressants that affect serotonin. Both drugs affect the serotonin transporter (like an SSRI) but also affect other serotonin receptors to relieve major depression.

Serotonin and norepinephrine reuptake inhibitors (SNRIs) are among the newer types of antidepressant. As the name implies, they block the reuptake of both serotonin and norepinephrine. They include duloxetine (Cymbalta), venlafaxine (Effexor), desvenlafaxine ER (Khedezla), levomilnacipran (Fetzima), and desvenlafaxine (Pristiq).

Norepinephrine and dopamine reuptake inhibitors (NDRIs) are another class of reuptake inhibitors, but they’re represented by only one drug: bupropion (Wellbutrin). It affects the reuptake of norepinephrine and dopamine.

My comments: In doing Part D prescription plan searches for clients, I have frequently run across the classic SSRIs such as fluoxetine, sertraline, and citalopram. I found it helpful to understand that venlafaxine and duloxetine are SNRIs and that bupropion is an NDRI. Note: These are the generic names for brand name drugs.

Continuing:

Older Antidepressants: Tricyclics and MAOIs

These drugs were among the first to be used for depression. Although they’re effective, they can have serious side effects and can be especially dangerous in overdose. Nowadays, many doctors only turn to these drugs when newer — and better tolerated — medicines haven’t helped. Tricyclics and MAOIs might not be the best approach for someone who was just diagnosed. But they can sometimes be very helpful for people with treatment-resistant depression, or certain forms of depression (such as depression with anxiety).

Tricyclic antidepressants (TCAs) include amitriptyline (Elavil), desipramine (Norpramin), imipramine (Tofranil), and nortriptyline (Pamelor). Like reuptake inhibitors, tricyclics seem to block the reabsorption of serotonin and epinephrine back into nerve cells after these chemicals are released into a synapse. Because of the potential side effects, your doctor might periodically check your blood pressure, request an EKG, or recommend occasional blood tests to monitor the level of tricyclics in your system. These medicines might not be safe for people with certain heart rhythm problems.

My comments: I found it helpful to learn that amitriptyline and nortriptylineare in an older class of antidepressants. It was also interesting to note that these drugs are prescribed when the newer antidepressants haven’t worked. Using WebMD. Reading this section about antidepressants was the longest time that I have used this website. One criticism that a reviewer on Vox.com had of WebMD was the tediousness of reading the site for information because of the bombardment of advertisements and popups. I found the same to be true. Nevertheless, despite the shortcomings and conflicts of interest concerning WebMD, it is possible to ferret out some useful information. End

Disclaimer

The articles in Northwest Senior News are for your education and general health information only, and the opinions of various writers do not necessarily reflect those of Northwest Senior News. The ideas, opinions and suggestions contained in Northwest Senior News are NOT to be used as a substitute for medical advice, diagnosis or treatment from your doctor for any health condition or related issues. Readers of Northwest Senior News should not rely on information provided in these articles for their own healthcare. Any questions regarding your own healthcare should be addressed to your own physician. Please do NOT start or stop any medications or any other medical protocol without consulting your doctor or other licensed healthcare practitioners.

Common Anti-Depressants

In Dr. Robert Lustig’s book The Hacking of the American Mind, Chapter 7, Contentment and Serotonin, Dr Lustig references older and common Selective Serotonin Reuptake Inhibitors (SSRIs) anti-depressants. Let’s learn a little more about them.

Prozac (generic name-fluoxetine): It is available as a liquid, tablet, capsule, and as a delayed-release, long-acting capsule.

From WebMD: Fluoxetine is used to treat depression, panic attacks, obsessive compulsive disorder, a certain eating disorder (bulimia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. Fluoxetine may lessen premenstrual symptoms such as irritability, increased appetite, and depression. It may decrease binging and purging behaviors in bulimia.

Side Effects: Nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning may occur. If any of these effects persist or worsen, tell your doctor promptly.

Precautions: Before taking fluoxetine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

From Wikipedia: Fluoxetine was discovered by Eli Lilly and Company in 1972 and entered medical use in 1986 It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is between US$0.01 and US$0.04 per day as of 2014. In the United States, it costs about US$0.85 per day. In 2016 it was the 29th most prescribed medication in the United States with more than 23 million prescriptions.

Common side effects include trouble sleeping, sexual dysfunction, loss of appetite, dry mouth, rash and abnormal dreams. Serious side effects include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior in people under 25 years old and an increased risk of bleeding. If stopped suddenly, a withdrawal syndrome may occur with anxiety, dizziness and changes in sensation.

From verywellmind.com: As an SSRI, Prozac works by preventing the brain from reabsorbing naturally occurring serotonin. Serotonin is involved in mood regulation. In this way, Prozac helps the brain to maintain enough serotonin so that you have a feeling of well-being, resulting from improved communication between brain cells.

Research also highlights how medications such as Prozac may help in combination with psychotherapy. In a 2008 study published in Science, it was shown that in mice, Prozac helped the brain to enter a more immature and plastic state, possibly making it easier for therapy to have an effect. We do know that combining medication such as Prozac with talk therapy is effective for anxiety, and this study indicates a potential reason why.

Zoloft: (generic name-sertraline):

From WebMD: Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. Sertraline is known as a selective serotonin reuptake inhibitor (SSRI). It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.

From Wkipedia: Sertraline was approved for medical use in the United States in 1991 and initially sold by Pfizer]] In 2016, it was the most prescribed psychiatric medication in the United States with over 37 million prescriptions.

From verywellmind.com: As with all medications, Zoloft may cause certain unwanted side effects. The most commonly experienced in those taking Zoloft include:

Diarrhea, Nausea, Indigestion, Decreased appetite, Fatigue, Sleepiness, Insomnia, Tremors, Agitation, Increased sweating, Sexual problems, including loss of libido and inability to ejaculate, Gastrointestinal problems can occur in as many as one in four people

There are some serious side effects associated with Zoloft use: Black or bloody stools, Chest pain, Fainting, Fast or irregular heartbeat, A severe or a persistent headache, Fever over 100 degrees F, Seizure, Suicidal thoughts, Stevens-Johnson syndrome (SJS), a rare but potentially fatal allergic reaction.

Celexa (generic name-citalopram):

From WebMD: Citalopram is used to treat depression. It may improve your energy level and feelings of well-being. Citalopram is known as a selective serotonin reuptake inhibitor (SSRI). This medication works by helping to restore the balance of a certain natural substance (serotonin) in the brain.

To reduce your risk of side effects, your doctor may direct you to start taking this drug at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Side effects: Nausea, dry mouth, loss of appetite, tiredness, drowsiness, sweating, blurred vision, and yawning may occur.

From Wikipedia: Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and social phobia. Benefits may take one to four weeks to occur. It is taken by mouth.

From Drugs.com: Celexa is made by Forest Laboratories, Inc.

From verywellmind.com: Celexa is an antidepressant medication that’s often prescribed to treat both mood and anxiety disorders. Celexa belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs).

How Celexa Works: Celexa balances your level of serotonin, a naturally occurring chemical substance or neurotransmitter in the brain. Serotonin is responsible for regulating sleep, mood, and other functions. Research has shown that imbalanced brain chemicals can contribute to mood and anxiety disorders, but the exact cause of panic disorder remains unknown. An SSRI like Celexa can assist in balancing serotonin by preventing the nerve cells in the brain from absorbing it. By reducing the rate at which serotonin is reabsorbed, Celexa changes your brain chemistry, improving mood and reducing feelings of anxiety. Celexa can assist in decreasing the severity of panic attacks and other panic disorder symptoms. Plus, Celexa can also reduce symptoms if you have a common co-occurring condition, such as depression.

Paxil (generic-paroxetine):

From verywellmind.com: Paxil is an antidepressant medication approved for the treatment of generalized anxiety disorder (GAD) and other anxiety disorders. It is in the same class as Prozac and Zoloft. Like other selective serotonin reuptake inhibitors (SSRIs), it was developed as a treatment for depression.

Paxil was approved for the treatment of generalized anxiety disorder (GAD) in 2001 and social anxiety disorder (SAD) in 1999. It is also a prescribed treatment for panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and obsessive-compulsive disorder (OCD).

Nerve impulses are transmitted chemically between neurons in the nervous system. Neurotransmitters like serotonin are produced by one neuron. They travel between the cells and are deposited on the second neuron. It is theorized by some that keeping the serotonin around longer results in relief of depression.

People with GAD develop chronic and exaggerated worry and tension, even though nothing seems to provoke it. Those with this disorder are always anticipating disaster. They often worry excessively about health, money, family, or work. Just the thought of getting through the day may provoke anxiety.

Many people with GAD realize that their anxiety is more intense than the situation warrants. This knowledge does not reduce the anxiety. They may report being unable to relax and often have trouble falling or staying asleep.

Their worries are usually accompanied by physical symptoms, especially trembling, twitching, muscle tension, headaches, irritability, sweating, or hot flashes. They may feel lightheaded, out of breath, nauseated or have to go to the bathroom frequently. They might also feel as though they have a lump in the throat.

Generalized anxiety disorder is usually treated with psychotherapy, medication, or a combination of the two. It can take some time to figure out the best combination for you, so be patient and keep your doctor informed about what is and isn’t working for you.

Common side effects of Paxil are nervousness, sleep difficulties (either too much or too little), restlessness, fatigue, dry mouth, nausea, headache, sweating, diarrhea, and sexual problems. Typically, these side effects will go away within a couple weeks of taking the medication.

For a complete list of other anti-depressants, please refer to this Wikipedia link.

Disclaimer

The articles in Northwest Senior News are for your education and general health information only, and the opinions of various writers do not necessarily reflect those of Northwest Senior News. The ideas, opinions and suggestions contained in Northwest Senior News are NOT to be used as a substitute for medical advice, diagnosis or treatment from your doctor for any health condition or related issues. Readers of Northwest Senior News should not rely on information provided in these articles for their own healthcare. Any questions regarding your own healthcare should be addressed to your own physician. Please do NOT start or stop any medications or any other medical protocol without consulting your doctor or other licensed healthcare practitioners.

Are Medicare Supplement Plans C and F going Away? Not quite!

Note: I thank Ron Iverson, president of NAMSMAP* for assembling this data. This information comes from the National Association of Insurance Commissioners. *National Association of Medicare Supplement and Medicare Advantage Producers.

1)  Why is the standard model for Medicare supplement (Medigap) plans being revised?

A new federal law was passed on April 16, 2015. The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) makes changes to Medigap policies that cover the Part B deductibles for “newly eligible” Medicare Beneficiaries on or after January 1, 2020.

2) What does MACRA require?

As of January 1, 2020, MACRA does the following:

2a) Prohibits first dollar Part B coverage on Medicare Supplement plans (Plans C and F) to “newly eligible” Medicare Beneficiaries, so Plans C and F cannot be sold to those “newly eligible” for Medicare. Those enrolled in Plans C and F prior to January 1, 2020 may keep their plan.

2b) Makes Plans D and G the guarantee issue plans for “newly eligible” Medicare Beneficiaries for the specified periods under current law that name C or F for current Medicare beneficiaries.

2c) Who is considered a “newly eligible” Medicare beneficiary under MACRA?

MACRA defines “newly eligible” as anyone who: (a) attains age 65 on or after January 1, 2020, or (b) who first becomes eligible for Medicare benefits due to age, disability or end-stage renal disease on or after January 1, 2020.

3) How much is the Medicare Part B deductible?

Medicare Part B deductible is $185 in 2019.

4) How does this relate to efforts to eliminate Medigap or Medicare supplement “first dollar coverage”?

This accomplishes the efforts to eliminate Medigap “first dollar coverage” (coverage of all claims without paying any out of pocket cost) by discontinuing sale of Plan C and Plan F only for “newly eligible” Medicare Beneficiaries

5) How are people eligible for Medicare on the basis of disability impacted by these changes?

Current beneficiaries are not impacted. The restrictions under MACRA apply to persons who qualify for Medicare as a result of a disability on or after January 1, 2020.

6) Why are plans “re-designated” for only “newly eligible” Medicare beneficiaries?

The Federal Government wanted to eliminate coverage for the Part B deductible making consumers responsible for that first dollar coverage. The only difference between Plans C and F and Plans D and G is the coverage of the Part B deductible under Plans C and F. All other benefits are exactly the same for D and G. Since Plans C and F will no longer be available for “newly eligible” beneficiaries, it was necessary to designate Plans C and F as Plans D and G for these individuals.

7) How are enrollees in current Plans C and F affected by these changes?

Current enrollees (those eligible for Medicare PRIOR to January 1, 2020) can continue with their Plan C or Plan F, including F High Deductible plan, and may continue to buy Plans C and F beyond January 1, 2020. Current enrollees will also be able to buy the new Plan G High Deductible plan on or after January 1, 2020.

8) What changes are made to High Deductible Plan options?

Since Plan F High Deductible cannot be sold to those “newly eligible” Medicare beneficiaries, a new Plan G High Deductible is created for those “newly eligible” Medicare beneficiaries as of January 1, 2020. The effective date of coverage for Plan G High Deductible must be on or after January 1, 2020. If you are not a “newly eligible” beneficiary and are enrolled in a Plan F High Deductible prior to January 1, 2020, you are able to continue this coverage beyond January 1, 2020 and to purchase this coverage on or after January 1, 2020.

9) When can the new High Deductible Plan G be sold and who can buy it?

Plan G High Deductible can be made available beginning on January 1, 2020; “newly eligible” Medicare beneficiaries and current beneficiaries would be able to buy the new Plan G High Deductible.

10) For high deductible plans, does payment of the Part B deductible count towards the plan deductible?

For Plan G High Deductible; while the Part B deductible is not covered (reimbursed), it does count towards the High Deductible plan’s deductible. If, in the rare circumstance the Plan G’s High Deductible is met with all Part A expenses and Part B Deductible expenses are then incurred, these expenses will not be covered expenses until the beneficiary meets the Medicare Part B deductible.

11) For the new High Deductible Plan G sold on or after January 1, 2020, what happens if a policyholder meets the high deductible amount with all Part A out of pocket expenses?

If, in the rare circumstance the Plan G’s High Deductible is met with all Part A expenses any Part B Deductible expenses incurred will not count towards meeting the High Deductible nor will they be covered expenses.

12) What changes are made to Guaranteed Issue requirements?

Since two of the current guaranteed issue plans, Plans C and F, will no longer be available for “newly eligible” Medicare Beneficiaries on or after January 1, 2020, Plans D and G will become two of the guaranteed issue plans for these individuals. Current enrollees can remain with or buy Plans C and F and individuals who do not fall within the definition of “newly eligible” Medicare beneficiary will still be able to purchase Plans C and F.

13) How does this change the way Plans C or F, and D or G, may be sold in the state?

Insurers can continue to sell Plans C or F to current Medicare beneficiaries. However, “newly eligible” Medicare beneficiaries cannot apply for or purchase Plan C or F. The “newly eligible” would be offered Plans D or G on a guaranteed issue basis instead. All other currently available plans may continue to be offered to all Medicare beneficiaries regardless of their date of eligibility for Medicare.

You are NOT considered “newly eligible” because you turned age 65 before January 1, 2020; and although you must enroll in Part B to purchase Medigap and that would occur after January 1, 2020, you could purchase C or F because you turned age 65 before January 1, 2020.  

Key Takeaways

1)  Plans C and F, and High Deductible F, will not be available to anyone who turns 65 (“newly eligible”) after January 1, 2020, including those eligible for Medicare by reason of disability.

2)  People currently with Plans C and F and High Deductible F will be able to keep them after the date.

3)  People who turn 65 and register for Medicare before the date, can still purchase Plans C and F because they are not considered “newly eligible.”

4)  And…even though a person who purchases Part B after January 1, 2020, they can still purchase Plans C or F because he/she turned 65 before the date.

5)  The current Plan C will become (be designated) the current Plan D after the date.

6)  The current Plan F will become (be designated) the Current Plan G after the date.

7)  All High Deductible Plan Fs will be available as they currently are after the date, and will become (be designated) High Deductible Plan G.  Available purchase will include people who turn 65 before the date, but again, not those “newly eligible.”

8) Guaranteed Issue (GI) Plans C and F will not be allowed to be sold to newly eligible, but GI plans D and G will.

9)  Plans K and L will remain the same, with the exception of the yearly raise of out-of-pocket expense.

10)  Plans M and N will not change.

11)  The rules also apply to “Medicare Select” plans.